New app allows users to select profiles by health goal and sustainability

Feb 16, 2022 12:27pm

It seems like the world of personalised nutrition is heating up with a flurry of investment rounds again. Get ready for a really packed edition.

In this week's newsletter: 

Lifenome accepted into LG nova's Mission for the future program, Vitl receives £6.5m investment, Luvo taps insurers to raise awareness of food as medicine, Elo raises $5mil, Personalised Nutri-score?, two podcasts and plenty more.

Yours in health,
CEO & Founder of Qina


Research update

Caloric restriction has a new player

This study led by Yale researchers identifies PLA2G7 as a protein of interest for calorie restriction effects. The findings suggested that PLA2G7 targets a specific mechanism of inflammation called the NLRP3 inflammasome. By lowering levels of PLA2G7 we can lower inflammation, and it has been identified as a driver of calorie restriction. “Identifying these drivers helps us understand how the metabolic system and the immune system talk to each other, which can point us to potential targets that can improve immune function, reduce inflammation, and potentially even enhance healthy lifespan.”, said the researchers.


Estimating impact of food choices on life expectancy: A modeling study

The Food4HealthyLife Calculator was developed at the University of Bergen (Norway) and calculates how many more years of life expectancy (LE) healthy foods can add to certain demographics. The findings have shown that the largest gains in years of LE would be made by eating more legumes, (adding 2.2 LE years to females and 2.5 to males), whole grains (females +2.0 years, males +2.3 years), followed by more nuts (females +1.7 years, males +2.0 years), less red meat (females +1.6 years, males +1.9 years), and less processed meat (females +1.6 years, males +1.9 years). If the person starts this diet at the age of 20, the model estimates women could increase their LE by 10.7 years and men by 13.0 years. If started at the age of 60 the increase of LE will be 8.0 years for women and 8.8 years for men. At the age of 80, they could gain 3.4 years on average, with females adding 2.1-4.7 of LE and males 2.1-4.8 of LE from such dietary changes.


Comment on Future trends in clinical genetic and genomic services by Borle et al.

This review quotes Borle et al. and the "uncertainty of the future of genetic and genomic service provision and provides some insight into perspectives of Canadian genetic professionals on the topic". Some of the discussion in this article was the universal usage of non-invasive prenatal screening including population-based genome-wide sequencing, the increase of Canadian genetic health care services until 2030, and the urgent need for human resource planning for clinical genetic and telehealth services to provide adequate access for all individuals in need. The discussion also highlighted the search for alternative service delivery models.


GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis

This study performed by an international team at Case Western Reserve University School of Medicine has discovered novel properties of the protein Gasdermin B (GSDMB) in Crohn's disease and ulcerative colitis patients. The GSDMB promotes the repair of cells lining the gastrointestinal tract. By analyzing samples from Crohn's disease and ulcerative colitis patients, the study found substantial increases of GSDMB in biopsies of those with IBD, particularly ulcerative colitis when compared to healthy individuals. Furthermore, increased GSDMB levels led to proliferation, migration, and decreased adhesion dynamics -- the attractive forces between cells and other surfaces that affect motility.


Clinical Practice Guidelines Using GRADE and AGREE II for the Impact of Genetic Variants on Plasma Lipid/Lipoprotein/Apolipoprotein Responsiveness to Omega-3 Fatty Acids

“A recent systematic review, which used the GRADE methodology, concluded that there is strong evidence for two gene-diet associations related to omega-3 and plasma triglyceride (TG) responses. Systematic reviews can be used to inform the development of clinical practice guidelines (CPGs). In conclusion: “Most of the evidence in this area is not ready for implementation into clinical practice primarily due to low scientific validity (low quality of evidence). However, the first CPGs in nutrigenetics have been developed for two nutrigenetic associations with strong scientific validity, related to dietary/supplemental omega-3 and TG responses.”


Diverging metabolic effects of two energy restricted diets differing in nutrient quality: a 12-week randomized controlled trial in subjects with abdominal obesity

This 12-week study aimed "to examine the additional effects of nutrient quality on top of 25% of energy restriction(ER)", in participants aged 40-70 years with abdominal obesity divided into three groups (a 25%ER high nutrient quality diet (n = 40); a 25%ER low nutrient quality diet (n = 40); or a habitual diet (n = 30). The high nutrient quality ER diet was enriched in monounsaturated and n-3 polyunsaturated fatty acids, fiber, and plant protein and reduced in fructose. The results have shown that "The high-quality ER diet-induced 2.1 kg more weight loss than the low-quality ER diet, reduced fasting serum total cholesterol and plasma triglycerides, promoted an anti-atherogenic lipoprotein profile and induced a more pronounced decrease in adipose tissue gene expression. Also, the difference in weight loss between both ER diets was specifically present in insulin-sensitive subjects, in whom the high nutrient quality diet-induced 3.9 kg more weight loss than the low nutrient quality diet".


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Technology News

Lifenome accepted into LG NOVA Program

Lifenome has been selected by LG NOVA’s team of leading emerging technology and entrepreneurial experts to advance to the next round of the incubator phase. The programme has selected startups that will have the most immediate impact on society now and in the future

Related Articles:

PNU 15.2021 Lifenome launches World’s 1st Platform For Precision Pregnancy Nutrition


Fitbit tests ‘Quantified Self’ program where you ‘experiment on yourself’ to find activities that work

"Quantified Self" is a new service provided by Fitbit that’s personalized and involves using Fitbit data to figure out which strategies can meaningfully boost customers' aims. After the walkthrough and self-assessment prompts, the app offers strategies grouped under fitness, mindfulness, sleep, and nutrition categories. Each lasts 28 days, with Fitbit prompting you about progress throughout for self-ratings. Fitbit uses heart, sleep, and weight metrics over 28 days to determine whether a strategy was beneficial to the customer. A dashboard is available to view notes on trends and changes over the four weeks.


Performance Kitchen taps healthcare insurers to raise brand awareness, sell food as medicine

Luvo has become Performance Kitchen, a company of frozen meals created by doctors, registered dietitians, and chefs with the mission of "food as medicine". With more than 60 different meals spanning many dietary needs including plant-based, low carb, gluten-free, dairy-free, and chronic conditions, the company has also made partnerships with several insurers, including Medicare and Medicaid.


Nutrition Startup Raises Funds From Former NFL Player, Oura Founder

The San Francisco-based personalized nutrition company Elo provides personalized nutrition supplements and a nutrition tracking app through an at-home blood test, activity metrics from wearables, and artificial intelligence. They have announced a raise of $5 million, with the investments of former National Football League player Isaiah Kacyvenski (now a co-founder and managing partner at Will Ventures), Petteri Lahtela, co-founder of the wearable sleep tracker Oura ring, Robin Thurston, the CEO of Outside Inc., and Ilkka Paananen, co-founder of video game maker Supercell Oy. 


WearTech project from Aventyn: MEALWATCH from Nium

The WearTech project from Aventyn is an accelerator on healthcare products that is supporting Nium and his new study: the MEALWATCH. Mealwatch is a study in partnership with ASU College of Health Solution Integrating Intel IoT, and aims to validate an innovative personalized wearable and meal recommender app with real-time nutritional assessment as a novel digital health solution for personalized nutrition guidance with meal recipes. The target will be clinicians and clinical dietitians to better manage patients to prevent malnutrition.

#070 Dr. Eran Elinav on Microbiome Insights into Personalized Response to Diet, Obesity, and Leaky Gut

Podcast with Eran Elinav, MD, Ph.D. (professor of immunology and principal investigator at the Weizmann Institute of Science in Tel Aviv, Israel and principal investigator at the German Cancer Research Center in Heidelberg, Germany) about several topics on personalized nutrition and microbiome.


How Nightingale Is Redefining Preventative Health

Interview with Nightingale CEO and Co-founder Teemu Suna about their blood testing technology and how it could change preventative health globally by getting patients to see their potential future and then change the course of their health.


Upcoming Events:

Personalized Nutrition Innovation Summit, Hologram Sciences in partnership with DSM, 21-22 February 2022

Food Innovation and Investment Summit, Kisaco Research, San Francisco, California, 18-19 May 2022