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A Systematic Review and Recommendations Around Frameworks for Evaluating Scientific Validity in Nutritional Genomics
This review, which analyzed 41 frameworks, aimed to examine the scientific validity of nutrigenetic research. The results show factors considered important for the evaluating of nutrigenetic evidence are: design and quality, generalizability, directness, consistency, precision, confounding, effect size, biological plausibility, publication/funding bias, allele, and nutrient dose-response, and summary levels of evidence. Also, "consideration of biological plausibility was more common in frameworks used in genetics [and] dose-response effects were rarely considered".
Loss of sucrase-isomaltase function increases acetate levels and improves metabolic health in Greenlandic cohorts
The sucrase-isomaltase (SI) c.273_274delAG loss-of-function variant is common in Arctic populations. This study aimed to describe the health of adults with a sucrase-isomaltase deficiency in two cohorts of Greenlandic adults (N=4,922 and N=1,629). The results show: "homozygous carriers of the variant had a markedly healthier metabolic profile than the remaining population, including lower BMI (β (SE), body weight, fat percentage, fasting triglyceride, and remnant cholesterol". They also had higher circulating levels of acetate. "These results suggest that sucrase-isomaltase constitutes a promising drug target for improvement of metabolic health and that the health benefits are mediated by reduced dietary sucrose uptake and possibly also by higher levels of circulating acetate".
“The current study aimed to gain causal insight to the role that taste plays in coffee drinking behavior. Genetically inferred caffeine and bitter taste perception contributed to coffee drinking behavior but, contrary to our hypothesis, to a weaker extent than genetically inferred caffeine sensitivity. Specifically, a greater preference for caffeine inferred by genetic differences in the physiological effects of caffeine leads to a stronger preference for the taste/smell of coffee inferred by liking-scales and reported intake. Similar findings were reported for tea but also dark chocolate”.
Ness is a credit card that helps people get healthier. By earning points for healthy purchases, the card gives customers access to exclusive perks to complement their lifestyle. For example, the perks can include training sessions, wearables, or supplements.
Replacing meat with alternative plant-based products (RE-MAP): a randomized controlled trial of a multicomponent behavioral intervention to reduce meat consumption
Thorne HealthTech's First-of-Its-Kind 'Wellth Report' Reveals Shifts in Individuals' Health Behaviors with Ripple Effects for the Healthcare Industry and Broader Workforce
- "More than half (67%) of survey respondents revealed they continue to experience the negative impacts of COVID-19 on their personal health and wellness over the past year and a half;
- 89% of respondents tried to improve at least one area of their health in the past 12 months, the momentum that continues when they set future health goals;
- 55% of adults rate their sleep quality as fair or poor and 38% rated their mental health as fair or poor, and these numbers are higher for women, younger individuals, and those in lower income brackets".
This document provides an introduction to the MHRA’s real-world data (RWD) guideline series and points to consider when evaluating whether a RWD source is of sufficient quality for the intended use.
RWD is defined as data relating to patient health status or delivery of health care collected outside of a clinical study. Sources of RWD include electronic healthcare records (EHR) defined as structured, digital collections of patient-level medical data, primary and secondary care records, disease registries, and administrative data on births and deaths. Other sources of RWD include patient-reported outcomes (PRO) data and data which is collected outside of a clinical study setting such as through wearable devices, specialized/secure websites, or tablets.