For the science geeks, this week is a treat with some seriously interesting research articles and some super updates in the industry including: Caligenix releasing two new products leveraging mRNA, Zoe announces $53m investment round. Nestle acquires The Bountiful company, Mintel launches their future of nutrition report and don't forget to grab your 10% discount for the upcoming summit.
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In the Headlines - Personalised nutrition company Zoe receives $53m in series B-round
The recent round of funding will be used to further roll out the Zoe program which includes a home testing kit that promises to deliver personalised nutrition advice. Their research revealed the 90% of participants had more energy, 80% felt less hungry and lost an average of 11 pounds after the 3 month program. For the full article, click here.
"The review aims to provide a summary of current controversies in the field of nutrigenomics, and highlights recent research on the potential impact of implementing genetic testing for personalized nutrition in practice".
This article explores "the links among postprandial glucose, appetite and subsequent energy intake in 1,070 participants from a UK exploratory and US validation cohort, who consumed 8,624 standardized meals followed by 71,715 ad libitum meals, using continuous glucose monitors to record postprandial glycaemia". The results show "for participants eating each of the standardized meals, the average postprandial glucose dip at 2–3 h relative to baseline level predicted an increase in hunger at 2–3 h (r = 0.16, P < 0.001), shorter time until next meal (r = −0.14, P < 0.001), greater energy intake at 3–4 h (r = 0.19, P < 0.001) and greater energy intake at 24 h (r = 0.27, P < 0.001)".
This study aimed to "develop a metabolomic-based model capable of classifying individuals into dietary patterns and to investigate the reproducibility of the model". Using an independent cohort, A-DIET Confirm (n = 175), the individuals were divided into four dietary patterns. This was done by examining the differences in nutrient biomarkers. The four dietary patterns were: Moderately Unhealthy, Convenience, Moderately Healthy, and Prudent. The results suggest: "The Moderately Unhealthy and Convenience patterns had lower adherence to the Alternative Healthy Eating Index (AHEI) and the Alternative Mediterranean Diet Score (AMDS) compared to the Moderately Healthy and Prudent patterns (AHEI = 24.5 and 22.9 versus 26.7 and 28.4, p < 0.001). The dietary patterns were replicated in A-DIET Confirm, with good reproducibility across four-time points. The stability of participants' dietary pattern membership ranged from 25.0-61.5%".
This review approaches gut microbiome health and outlines directions for developing targeted ecological therapeutics. The objectives: "emphasizes the importance of identifying which ecological features of the gut microbiome are most resonant with host molecular phenotypes, and highlights certain gut microbial metabolites as potential biomarkers of gut microbiome health. (...) [also] discusses how multi-omic measurements of host phenotypes, dietary information, and gut microbiome profiles can be integrated into increasingly sophisticated host-microbiome mechanistic models that can be leveraged to design personalized interventions".
Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome
This study aims "to unravel interactions between diet, gut microbiota and their functional ability to induce intestinal inflammation". The method used investigated "the relation between 173 dietary factors and the microbiome of 1425 individuals spanning four cohorts: Crohn’s disease, ulcerative colitis, irritable bowel syndrome, and the general population". The results show "38 associations between dietary patterns and microbial clusters. Moreover, 61 individual foods and nutrients were associated with 61 species and 249 metabolic pathways in the meta-analysis across healthy individuals and patients with IBS, Crohn’s disease, and UC (false discovery rate<0.05). Processed foods and animal-derived foods were consistently associated with higher abundances of Firmicutes, Ruminococcus species of the Blautia genus, and endotoxin synthesis pathways. The opposite was found for plant foods and fish, which were positively associated with short-chain fatty acid-producing commensals and pathways of nutrient metabolism".
Sodium Sensitivity, Sodium Resistance, and Incidence of Hypertension - A Longitudinal Follow-Up Study of Dietary Sodium Intervention
This Chinese study aims to relate the high sodium sensitivity to hypertension. The researchers conducted "a feeding study, including a 7-day low-sodium diet (1180 mg/day) followed by a 7-day high-sodium diet (7081 mg/day), among 1718 Chinese adults with blood pressure (BP) <140/90 mm Hg", and "followed them over an average of 7.4 years". The results show "mean (SD) changes in systolic BP were −13.7 (5.5), −4.9 (3.0), and 2.4 (3.0) mm Hg during the low-sodium intervention and 11.2 (5.3), 4.4 (4.1), and −0.2 (4.1) mm Hg during the high-sodium intervention (P<0.001 for group differences) in high sodium-sensitive, moderate sodium-sensitive, and sodium-resistant groups, respectively". This shows that "individuals with either high sodium sensitivity or sodium resistance are at an increased risk for developing hypertension"
Combined analysis of gut microbiota, diet, and PNPLA3 polymorphism in biopsy‐proven non‐alcoholic fatty liver disease
“In this cross‐sectional study, we performed 16S gene sequencing using fecal samples, collected dietary intake, PNPLA3 gene variants, and clinical and liver histology parameters in a well‐described cohort of 180 NAFLD patients.” In conclusion, the results showed "BMI had the strongest association with histological fibrosis, but PNPLA3 gene variants, gut bacterial features, and dietary factors were all associated with different histology features, which underscores the multifactorial pathogenesis of NAFLD".
This article describes the importance of creating new nutrition policies that equally address food quantity and quality. The approach should be current and "the health profile in the US looks very different from that of half a century ago when hunger was prioritized, and from several decades ago when food insecurity became the focus. In recognition of the rapid increase in the prevalence of several diet-related diseases and long-standing racial disparities in access to nutritional foods and diet-related conditions, it is time to embrace the concept of nutrition security".
Genetic Wellness Company, Caligenix to Launch Personalized Skincare and Nutrition Brands Leveraging Real-Time RNA
Caligenix® has announced the launching of two genomic-based wellness brands: Dermatype™ and Biotype™. Backed by years of DNA research and data, their products are designed with advanced technologies, science-based AI algorithms, and genomics, giving consumers complete insight into their unique needs. These new products will be formulated based on people’s individual genomic DNA.
Currently, the obesity treatment is based on "trial and error", but Andres Acosta, MD, PhD, assistant professor of medicine and director of the precision medicine for obesity program at Mayo Clinic, spoke about the benefits of phenotype-guided obesity interventions, determined by a blood test, at the Obesity Medicine Association 2021 virtual conference. In a study performed on more than 450 participants, Acosta and his colleagues categorized the participants into four phenotypes: "Hungry brain”; “Hungry gut”; "Emotional hunger” and “Slow burn”. By knowing the pathophysiological and behavioral phenotypes and recognizing individual variabilities the obesity treatment will be more accurate and personalized.
The FoodTech: Health & Wellness start-up program was launched by Sente in partnership with Griffith Foods, Yıldız Holding, and Ingredion. This program is conducted to start-ups in an early stage with novel ingredients, food products, packaging, processing technologies, and new experiences that cater to rapidly evolving consumer needs and desires.
The app "Informed Sport" launched by UK-based life science firm LGC, "allows users to quickly determine whether a sports nutrition product has been certified to ensure it does not contain a prohibited or harmful substance". (...) [the app] uses a barcode scanning technology that allows supplement users to access product information including certification status and approved batch/ lot numbers".
"Nestlé has entered an agreement with global investment firm KKR to acquire the core brands of The Bountiful Company for US$5.75 billion, expected to close in the second half of 2021. The transaction includes the “high-growth” brands Nature’s Bounty, Solgar, Osteo Bi-Flex, and Puritan’s Pride, as well as the company’s US private label business, which will be integrated into Nestlé Health Science".
Join us for the upcoming not-to-be-missed Personalised nutrition Summit where we are speaking and judging!
Food & Consumer Trends
Plant-based, vegetarian and vegan options have become “the dominant dietary trend” in recent years, and sports nutrition ingredients have also adapted their ingredients to consumer and diet trends. From the expansion of creatine-based ingredients to protein, plants, and bacteria, new ingredients and formulas have been created for the industry of sports nutrition.
Mintel has launched the Future of Nutrition, Health, and Wellness 2021 Report, which shows the rising interest in holistic health now and in the near future.
- "(...) 70 percent of Chinese consumers regularly include immune-boosting food in their diet because of COVID-19, and 50 percent plan to continue doing so in 2021;
- In Brazil, 56 percent of consumers aspire to eat a diet that reduces the risk of lifestyle diseases such as hypertension and diabetes;
- (...) 78 percent of US consumers say eating healthy is important for their emotional wellbeing, whereas in China, 44 percent of adults aged 18-59 believe having a good gut reduces anxiety.
- (...) three in four Mexican consumers (71 percent) agree that it’s harder to eat healthily when money is tight, and one-third of Chilean consumers (34 percent) strongly agree that healthy food is too expensive to buy on a regular basis"
The COVID-19 pandemic has changed life for everyone, “remote work is increasing and information needs to be processed at a much higher speed (...) at the same time, the balance between professional and private life has become more difficult for many consumers”. These facts, together with the emerging gaming focus have opened an opportunity to the nootropics industry. It has been one of the fastest-growing segments in the nutrition and health industry and was valued by several reports at US$2.2 billion in 2019. In 2027, it is expected to reach US$6 billion.
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