After months of testing and sleepless nights, we are ready to launch our new and improved Qina platform. It is such an exciting journey and the learning curve is steep!, nevertheless we want to continue leading in this field and making an impact by developing useful resources and services that can shape the future of nutrition and health.
In this week's newsletter: New Whitepaper on PN published; latest research; Edamam partners to provide CO2 imprint of meals and recipes;Thorne gets listed on the Nasdaq and much more!
New and improved Qina platform
This week we are launching our improved Qina platform which includes an extended database of PN companies, a market data dashboard and curated content. The Qina platform is available on subscription, you can read more here.
Not a member yet?, get in touch to learn more about our subscriptions for startups and companies.
Baseline Gut Metagenomic Functional Gene Signature Associated with Variable Weight Loss Responses following a Healthy Lifestyle Intervention in Humans
This review relates "the interactions between baseline BMI, metabolic health, diet, gut microbiome functional profiles, and subsequent weight changes in a human cohort that underwent a healthy lifestyle intervention." The results suggest, "that the microbiota may influence host weight loss responses through variable bacterial growth rates, dietary energy harvest efficiency, and immunomodulation."
Weight-Loss Strategies for Prevention and Treatment of Hypertension: A Scientific Statement From the American Heart Association
"Losing 5% to 10% of body weight can lead to a more than 5-mmHg reduction in systolic blood pressure and a 4-mmHg reduction in diastolic blood pressure, the statement notes. Losing 10 kg may lower systolic blood pressure by 5-20 mmHg". The American Heart Association (AHA) released a new statement that focuses on obesity as a primary risk for hypertension and highlights the importance of weight-loss strategies and the application of healthy lifestyles, referring to Mediterranean diet or the Dietary Approaches to Stop Hypertension (DASH) diet as recommendable guidelines to hypertension treatment.
Increasing the availability and utilization of reliable data on population micronutrient (MN) status globally: the MN Data Generation Initiative
"Available information indicates that several key MN (micronutrient) deficiencies are responsible for a sizable share of the morbidity and mortality experienced by young children and women of reproductive age in LMICs (low- and middle-income countries). (...) This report describes the current situation with regard to data availability, the reasons for the lack of relevant information, and the steps needed to correct this situation, including implementation of a multi-component MN Data Generation Initiative to advocate for critical data collection and provide related technical assistance, laboratory services, professional training, and financial support."
This review highlights the findings that genetic differences among individuals strongly affect the response to dietary fat. It shows that "calories from different macronutrient sources have metabolic effects beyond their simple numeric caloric value, and the effects of different types of calories may vary among individuals".
Variation in the vitamin D receptor gene, plasma 25-hydroxyvitamin D, and risk of premenstrual symptoms
This study performed on 760 women aged 20-29 years old from the Toronto Nutrigenomics and Health, aimed to determine whether associations between vitamin D status and individual PMSx (several premenstrual symptoms) are influenced by the VDR genotype. The results show "Among CC homozygotes, insufficient vitamin D status was associated with higher odds of experiencing premenstrual fatigue and nausea. Among TT homozygotes, insufficient vitamin D status was associated with lower odds of experiencing fatigue and increased appetite. Insufficient vitamin D status was associated with higher odds of increased appetite in women with the CT genotype."
The k-Nearest Neighbors (KNN) is a sugar prediction algorithm. This study aims "to develop a machine learning approach for the prediction of added sugar content in packaged products using available nutrient, ingredient, and food category information". The algorithm has been tested on 500 Australian packaged products. The results show "compared to the existing added sugar prediction approach, the KNN approach was similarly apt at explaining variation in added sugar content and ranking products from highest to lowest in added sugar content."
This study aims to "evaluate the association of the Mediterranean lifestyle (MEDLIFE) with the risk of depression", in 15,279 participants of the “Seguimiento Universidad de Navarra” (SUN) cohort. The final scores of MEDLIFE ranged from 0–28 points, and the participants were categorized into four quartiles of adherence. The results show: "after a mean follow-up of 11.7 years, 912 (6%) incident cases of depression were reported. The mean final score for MEDLIFE adherence was 11.9 points. The multivariable model showed that compared to the first quartile, the second and third quartiles of MEDLIFE adherence were significantly associated with a decreased relative risk for incident depression".
This review approaches the molecular mechanisms of physical activity. "Genetic and genomic analyses have identified genetic variation associated with human performance and, together with recent proteomic, metabolomic and multi-omic analyses, are beginning to elucidate the molecular genetic mechanisms underlying the beneficial effects of physical activity on human health".
Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity are often classified as distinct diseases. This review aims to show that both forms of obesity may share genetic and biological underpinnings, pointing to the brain as a key role in the control of body weight.
Edamam has announced a partnership with the City University of London, to provide customers, the estimated CO2 impact levels for about 5 million English online recipes of which 70,000 most commonly eaten meals worldwide. "The capability is initially available via Edamam’s Recipe Search API, where people will be able to find recipes based on their estimated CO2 emissions footprint. Next, Edamam will make the functionality available to clients who wish to calculate the CO2 impact of their recipes or meals and provide such data to end consumers. This functionality will be offered via the Company’s Nutrition Analysis API and will be provided ad hoc to businesses such as restaurants, catering companies, recipe developers, and food delivery companies".
Tamar Samuels and Vanessa Rissotto are the two registered dieticians that founded "Culina Health'', a virtual nutrition coaching platform that offers personalized dietician services that meet the unique needs of its users. In a time where nutrition and diets are fads, this startup aims to combine evidence-based nutrition with health coaching techniques.
Thorne HealthTech is now listed on the Nasdaq. This next chapter as a public company will accelerate its mission of transforming the approach to health and wellness by empowering individuals to live healthier lives through testing, teaching, and innovative solutions.
Fullscript partners with 3x4 Genetics
Fullscript is a free online platform that allows supplement dispensary & patient adherence tools. 3x4 genetics is an integrative healthcare company that uses the power of genetic testing to help practitioners create personalized health plans. They’re thrilled to announce their latest partnership.
Abnormal is a personalized meal replacement startup that, by filling a quick online questionnaire on diet, health goals, allergies, and lifestyle, provides a box with personalized shakes with the ideal amount of nutrients for the customers' needs. Abnormal is a parent company of The Protein Works (TPW).
Personalized Nutrition Whitepaper:
Finding the right Business Model to overcome the Valley of Death
We recently contributed to this hot off the press white paper on Personalised nutrition. It is a fantastic and free paper. Click on the image to follow download and let us know what you think!
Food & Consumer Trends
After Australia, New Zealand and Canada, implement the public health policy of adding folic acid into their food to prevent neural tube defects in babies. The UK will add folic acid into foods made with flour, such as bread, to help avoid around 200 neural tube defects every year (around 20% of the annual UK total). Non-wholemeal flour is already an established vehicle for fortification in the UK, and the costs of fortification to the industry are expected to be minimal.
This new market research conducted by ADM shows that consumers are becoming more educated about the importance of maintaining a healthy microbiome for their holistic health. Findings show that shoppers are searching for foods, beverages, and dietary supplements that proactively support both elements for wellbeing (pro-, pre-, post - and synbiotics). Citrus and botanicals that consumers associate with vitamin C and immune function support are catching their attention. Easy and drinkable systems, such as beverages, dairy, and supplements are the top 3 preferred probiotic categories.
The Millennials and Z Generation are making conscious brand choices based on values rather than cost. When this level of awareness and dedication occurs, the brands have to readapt. Transparency, authenticity, and disruptive innovation are now more important than ever. The new consumers are attentive and well-informed, and they have the interest to know the effect of the ingredients on their bodies. Non-GMO ingredients, transparent food labelling with nutritional facts, ethnically “inspired” foods, culinary tourism, and scientifically-supported food are some of the changes in the food industry done by these new generations.