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In this week's newsletter: Latest research, Lifenome launches world's first precision pregnancy platform, Greenchoice lets you shop by values, Remedy health gets a boost, and mental health ranks as top health concern according to Euromonitor.
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VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics
"This study aimed to explore the molecular mechanisms behind the memory seen in muscle stem cells from individuals with T2D, which may contribute to an altered myogenic potential, reduced muscle function, and hyperglycemia". The researchers found "lower VPS39 expression in myoblasts and myotubes from individuals with T2D. VPS39 is a previously unrecognized regulator of human muscle regeneration and function. VPS39-deficiency in human muscle stem cells gave rise to impaired autophagy, perturbed insulin signaling, and, based on mRNA microarray data, appeared to alter the well-known metabolic switch from glycolysis in myoblasts towards fatty acid oxidation and use of amino acids in myotubes. This resulted in abnormal regulation of epigenetic enzymes and the epigenome, and aberrant expression changes of myogenic regulators as well as gene sets related to the cell cycle, apoptosis, and glucose metabolism."
Flavonoid consumption and cardiometabolic health: Potential benefits due to foods, supplements, or biomarkers?
"Higher intake of fruit and vegetables, nuts, and whole grains has each been prospectively associated with lower morbidity and mortality of cardiometabolic diseases (CMDs) in adults (1–4). These consistent observations from high-quality and large prospective cohorts strongly implicate that substances rich in plant foods may confer important cardiometabolic benefits. Yet, it remains a matter of debate which specific micronutrients, minerals, phytochemicals, and/or bioactive components of these plant foods may be responsible for cardiometabolic protection (5). Polyphenols such as flavonoids have been shown to have antioxidant, anti-inflammatory, and antithrombotic properties and may improve vascular endothelial function, insulin secretion, and action, as well as lower blood pressure (6)...."
Differences in health-related biomarkers profile of vegetarians and meat-eaters: A cross-sectional analysis of the UK Biobank study
"Biomarkers have been widely used to assess the effect of diets on health. However, evidence of the metabolic benefits associated with being vegetarian is inconclusive. The aim of this study was to investigate the associations of vegetarian and meat-eater with 19 health-related biomarkers in healthy adults. In conclusion, vegetarians have a more favourable biomarkers profile than meat-eaters. These associations were independent of adiposity and other sociodemographics and lifestyle-related confounding factors."
The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics
"The purpose of this panel was to consider the scientific, commercial, and regulatory parameters encompassing this emerging term [postbiotic], propose a useful definition, and thereby establish a foundation for future developments.” The panel defined a postbiotic as a “preparation of inanimate microorganisms and/or their components that confers a health benefit on the host”. Effective postbiotics must contain inactivated microbial cells or cell components, with or without metabolites, that contribute to observed health benefits. The panel also discussed existing evidence of health-promoting effects of postbiotics, potential mechanisms of action, levels of evidence required to meet the stated definition, safety and implications for stakeholders".
This study aimed “to determine if following a Mediterranean-like diet (MeDi) relates to cognitive functions and in vivo biomarkers for Alzheimer’s disease (AD)". Using data from the German Longitudinal Cognitive Impairment and Dementia Study, the sample "(n=512, mean age: 69.5±5.9 years) included 169 cognitively normal participants and subjects at higher AD risk (53 AD relatives, 209 SCD and 81 MCI)". The results show "that Higher MeDi adherence related to larger mediotemporal gray matter volume (p<0.05 FWE corrected), better memory (β±SE = 0.03 ± 0.02; p=0.038), and less amyloid (Aβ42/40 ratio, β±SE = 0.003 ± 0.001; p=0.008) and pTau181 pathology (β±SE = -1.96±0.68; p=0.004)". In conclusion "MeDi as a protective factor against memory decline and mediotemporal atrophy".
Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18–25 years) with corresponding changes in gut bacterial composition
This study "examined multiple indices of mood and well-being in 64 healthy females in a 4-week double-blind, placebo-controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention". The researchers "obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses". The results show that "GOS prebiotic may improve indices of pre-clinical anxiety", specifically high trait anxiety and attentional bias.
Interaction between the dietary indices and PPAR-γ Pro12Ala gene variants on cardiovascular risk factors in patients with type 2 diabetes mellitus
This cross-sectional study was conducted on 393 diabetic patients and "investigated the interaction between peroxisome proliferator-activated receptor gamma (PPAR-γ) Pro12Ala polymorphism and Healthy Eating Index (HEI), Dietary Quality Index-International (DQI-I) and Dietary Phytochemical Index (DPI) on Cardiovascular Disease (CVD) risk factors in patients with type 2 diabetes mellitus (T2DM)". The results show that: "Higher dietary indices (DQI-I, DPI, HEI) may affect the relationship between PPAR-γ Pro12Ala polymorphism and waist circumference, ghrelin, leptin, HDL and IL-18 concentration in patients with T2DM".
GreenChoice is an online market that allows users to filter items by their diet—whether vegan, gluten-free, low-sodium, or an array of allergies—and by their values, such as organic, low carbon footprint, or even no palm oil. It works by answering a quiz "which asks if you follow a certain diet—(...) —or have any allergies, and to rate on a scale of 1 to 10 how important you find four different values: nutrition, processing, food safety, and the environment." “It’s an online marketplace where users can shop from Walmart, Target, or Walgreens, and filter their choices by more than 90 food preferences or values.” Greenchoice also invests in wind power and reforestation projects by donating the estimated carbon footprint of the order.
"The food tech brand, which claims to have developed the world’s first genetically personalised nutrition shake, secured the backing of Peter Jones and Touker Suleyman on the BBC One programme aired on 6 May 2021."
"LifeNome, the award-winning precision health AI company, launched the world’s 1st precision nutrition pregnancy platform on Indiegogo last week. Called 9Moons, the platform is a response to the need of pregnant women to address their unique prenatal nutrition needs and a response to the growing number of nutrition-related pregnancy complications, the latter of which is nearly 100% higher now than two decades ago. "
To regulate e-commerce the European Commission (EU) proposed two legislative initiatives to upgrade rules governing digital services in the EU: the Digital Services Act (DSA) and the Digital Markets Act (DMA). The objective is to create a new set of rules applicable across the whole EU to create a safer and more open digital space.
In short, "The DSA and DMA have two main goals:
to create a safer digital space in which the fundamental rights of all users of digital services are protected;
to establish a level playing field to foster innovation, growth, and competitiveness, both in the European Single Market and globally".
Nutrition Company Remedy Health Raises $11 Million, Makes Foray Into Protein Bars In Collaboration With ADM
"RiverPark Ventures-backed personalized nutrition company Remedy Health that offers a line of vitamin gummy products Nourished made with its patented 3D printing technology has raised an $11 million series A fund led by ADM Ventures and Cibus Fund, after seeing its revenue grow by more than 600% over the past year. The round of financing, which also includes follow on investments from Apater Capital and Henkel X, brings the UK-based company’s total value to more than $71.6 million."
Join us for the upcoming not-to be missed Personalised nutrition Summit where we are speaking and judging!
Food & Consumer Trends
ShareAction is an investment group that has created the first health-based shareholder resolution filed at a UK-listed company. The company involved is Tesco which has a 27% share of the UK grocery market. Tesco has agreed to increase sales of healthy products from 58% to 65% of total sales in its UK and Irish stores by 2025. The same should happen in their Central European stores. "These new commitments will ensure that every customer – wherever and however they shop with us – will have even greater access to affordable, healthy, and sustainable food," said Sarah Bradbury, Tesco's group quality director.
How do consumers around the world feel about the consumption of cell-based meat products? Several studies showed controversial results:
In Australia, "72% of the consumers are not ready to accept lab-grown meat";
"Younger generations [under 55 years] were keener to try this kind of product (...) [but] when you go 55 years and older, there was a little bit more resistance for the concept"
When consumers understood the concept of the product and the sustainability for the planet, the number of individuals that would purchase increases (in a survey of 1,000 people, 41% agreed they would try this type of product);
In terms of flavor: only 28% of consumers think that the taste of meat alternatives is 'good' or 'very good'. One in three consumers...would pay more for meat alternatives if they tasted similar to meat.
In January and February 2021, Euromonitor International conducted a survey that shows the pandemic impact on consumers' perceptions and purchasing habits relating to health, nutrition, and supplements. The results have shown an interest in health and wellness-related products, with 31% of consumers claiming they use vitamins and dietary supplement products daily or almost every day in 2021, compared to 26% in 2020 pre-pandemic, and 24% in 2019. Another tendency revealed by the Euromonitor survey is a shift in the trust of the consumers to digital information sources ("42% of respondents said they were 'very' or 'extremely' comfortable to consult a therapist online or via app in 2021"). When consumers were asked what "being healthy" means, the "mental wellbeing" came out as the top concern. The survey also showed an increase in the number of people exercising since the COVID-19 hit.
"This textbook provides an overview of recent reviews and studies of physiological and biochemical contributions to IFMNT (Integrative and Functional Medical Nutrition Therapy) and address nutritional influences in human health overall, including poor nutrition, genomics, environmental toxicant exposures, fractured human interactions, limited physical movement, stress, sleep deprivation, and other lifestyle factors".