How your gut fights back when you go on a diet

Dec 11, 2020 11:29am

Personalized nutrition update issue nr. 21

It’s that time of the year when we start winding down and recharge as schools close, so this will be our last eblast for the season. We will be back in early September with plenty of news to share.
 Is your Supply chain diverse?
For all the talk of major change in wake of recent developments regarding Equality, justice and Diversity there is actually very little happening when it comes to real action for companies and organizations. When it comes to the Personalised Nutrition industry, there is certainly a long way to go, as I have frequently commented that I am usually an “only” in the room full of industry leaders, CEO’s and managers. Read my latest blog post on what companies in the industry can do right now, to improve and act on diversity measures. Click here


Research Update

Systematic Review and Meta-Analysis of Candidate Gene Association Studies With Fracture Risk in Physically Active Participants

“Genetic differences have been shown to influence the inter-individual variability in fracture risk (Efstathiadou et al., 2001; Mann et al., 2001; Ji et al., 2010; Trajanoska et al., 2018) with heritable factors associated between 20 and 54% of fracture liability depending on site and age (Andrew et al., 2004; Michaëlsson et al., 2005)”. This study is aimed “to meta-analyze the pooled results of candidate gene association studies with non-osteoporotic fracture risk in physically active humans”. By the use of 11 eligible studies published in English, it evaluated the associations of risk alleles in the COL1A1 (rs1800012), COL2A1 (rs412777), CTR (rs1801197), ESR1 (rs2234693 and rs9340799) LRP5 (rs3736228), VDR (rs10735810, rs7975232, rs1544410, and rs731236) genes with fracture incidence. The results showed that “no overall effect was found from the pooled results of included genetic variants on fracture risk in physically active participants. The COL1A1 Sp1 rs1800012 T allele may reduce fracture risk in physically active females but further high-quality research with sex-specific analysis is required”.


Multidimensional Impact of Mediterranean Diet on IBD Patients

This study attempts to “analyze the impact of the Mediterranean diet (Md) on the nutritional state, liver steatosis, clinical disease activity, and quality of life (QoL) in IBD patients”. The sample used was 142 IBD patients, 84 UC (ulcerative colitis), and 58 CD (Crohn’s disease), which followed the Mediterranean diet for 6 months. The body mass index (BMI), body tissue composition, liver steatosis and function, serum lipid profile, clinical disease activity, and inflammatory biomarkers (C-reactive protein and fecal calprotectin) were collected at baseline (T0) and compared with those obtained after 6 months (T180) to evaluate the impact of Md. The results showed that “At T180, diet-adherent CD and UC improved BMI (UC −0.42, P = 0.002; CD −0.48, P = 0.032) and waist circumference (UC −1.25 cm, P = 0.037; CD −1.37 cm, P = 0.041). Additionally, the number of patients affected by liver steatosis of any grade was significantly reduced in both groups (UC T0 31 of 84 [36.9%] vs T180 18 of 84 [21.4%], P = 0.0016; CD T0 27 of 58 [46.6%] vs T180 18 of 58 [31.0%], P < 0.001) after dietary intervention. A    fter 6 months of the diet, fewer UC and CD patients with stable therapy had active disease (UC T0 14 of 59 [23.7%] vs T180 4 of 59 [6.8%], P = 0.004; CD T0 9 of 51 [17.6%] vs T180 2 of 51 [3.0%], P = 0.011) and elevated inflammatory biomarkers”.

 The Use of Behavior Change Theories in Dietetics Practice in Primary Health Care: A Systematic Review of Randomized Controlled Trials

This latest systematic review looks at the evidence of behavior change theory-based interventions delivered by credentialed nutrition and dietetics practitioners in primary health care setting. Findings suggest that Thirteen studies (68%) showed significant improvements for the primary outcome measured with Social cognitive theory the most frequently applied.


Long-term Dietary Intervention Reveals Resilience of the Gut Microbiota Despite Changes in Diet and Weight

There is growing interest in the potential role of gut microbes in weight loss. This recent study aimed to see if baseline microbiota diversity is associated with weight loss success. Before you get excited, there was no difference. Whilst microbiota changes were detected 3 months after the intervention as related to weight loss and specific dietary pattern followed (low fat or low carb), these changes were not maintained in the longer term.


Dietary metabotype modelling predicts individual responses to dietary interventions

In this feasibility study conducted at UCL ( London), an individual Dietary Metabotype Score (DMS) that calculates interindividual variability to dietary response was compiled.

and captures consequent dynamic changes in concentrations of urinary metabolites. The benefit of a dried urine metabolite test in clinical practice could mean that practitioners can check both adherence to dietary recommendations as well as get a better understanding of how an individual responds to dietary components.


Technology News

LOEWI GmbH receives seed financing to make personalized health and nutrition available for everyone

LOEWI GmbH is a scientific spin-off of the Technical Munich University that has a patented concept that analyzes health-relevant data of patients by the use of LOEWI’s health profile (medical software class I). In this way, it creates personalized nutrient recommendations and therapies using a sophisticated algorithm. On the other hand, High-Tech Gründerfonds (HTGF) is a seed investor that finances high-potential, tech-driven startups, and now has announced an investment in LOEWI. “The investment is an important step to push the development in the field of personalized nutrition and health and to lead the market out of its niche. The combination of science and technology will continue to be the cornerstone of our business. We are very pleased to welcome HTGF as a well-connected partner who supports our long-term vision”, said Adrian Kapsalis, founder, and CEO of LOEWI.

 Viome launches world’s first at-home service to measure and improve immunity, inflammation, gut health, and aging

Health Intelligence is a new service provided by Viome and is the world’s first at-home service to measure and improve immunity, inflammation, gut health, and aging. Through the RNA analysis, and analysis of the data expression of tens of thousands of human genes, microbial genes, and mitochondrial genes. Health Intelligence produces dynamic and actionable health insights on six main health category scores (Gut Microbiome Health, Cellular Health, Mitochondrial Health, Immune System Health, Biological Age, and Stress Response).


Lumen Launches Innovative Wellness Device

Lumen is the first handheld, portable device, and app that measures a person’s metabolism in real-time using just the breath. Lumen notes that research has found metabolic flexibility to have a profound role in assessing a person’s health. Through the measure of the body’s carbon dioxide concentration, the device indicates which type of fuel the body is using to produce energy. This valuable information helps the Lumen app to develop a nutritional plan, with suggestions of what to eat to fuel the body. In turn, improving metabolic flexibility (the ability to efficiently switch between using carbs and fats as a fuel source).


New urine test can tell if you are on the best diet for your body

This 5 minute-urine test has been in development by Imperial College for a while. Two recent publications in Nature Food journal (check research section above) underpin the metabotype test. The test is able to not only check adherence to diet but also identify metabolic response to dietary components.


Personalised nutrition meets food-tech and Covid-19

I was recently interviewed by the Investor journal regarding the emerging Personalised nutrition market as it pertains to Food-tech. You can read the full article here


My recent interview with the Virtual Global Village talking about my favourite topics, Personalised nutrition, health inequality, diversity and education



Food & Consumer Trends

Stress prevention replaces weight management as a top health concern, creating a marketing opportunity

New research from The Hartman Group shows that “for the first time in a decade, weight management is no longer America’s top health concern as anxiety and stress prevention and treatment rise to the No. 1 position of a long list of health conditions with which households are grappling”. In January 2019, 63% of US households were actively treating or preventing anxiety or stress – a 13% point increase since 2013. The treatment and prevention of fatigue and depression also increased significantly since 2013. One of the factors for this increase, according to the report, is the lack of sleep, with 32% of the responders reporting less sleep than they would like four or more days per week.
According to the International Food Information Council, annual report “Food & Health Survey”, 43% of Americans claimed they are following a specific diet or eating pattern (an increase since 2019 and 2018). Last year’s top diet was “clean eating” and in 2018 “ketogenic or high-fat diet”, but in 2020 the winner is “intermittent fasting” – that focuses more on when to eat than what to eat (or not eat). According to the report, about 10% of 1,000 Americans between 18 to 80 years are following intermittent fasting. The top motivator for adopting a new diet remains a desire to lose weight but more Americans reported caring more about their overall health.


Survey highlights brands most recommended by pharmacists

“The US News & World Report just released its lists of pharmacist-recommended over-the-counter medications and devices, which includes a number of dietary supplements. The annual survey, conducted in collaboration with Pharmacy Times, highlights these products. Nature Made emerged as a winner in nine key vitamin and supplement segments, including: Vitamins (A,B,C,D, and E), CoQ10, Omega-3/ Fish Oil, Flaxseed Oil, Herbal Supplements, Mood Health (SAM-e), Diabetic Multivitamins, Garlic, Cholesterol Management (Fish Oil).”


Upcoming Events


Foodmatterslive Personalised nutrition seminar 14th October 2020

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